-Have a bad temper
-Are extremely eager to study science
-Have a blonde sister-figure (okay, that one's kind of farfetched)
-Try to bring the dead back to life and create a monster instead
-Have to pay dearly for their transgression
-Read the works of Hohenheim (For Ed, it was his father's letters, for Victor, it was the books of Paracelsus, better known as Theophrastus Bombastus Hohenheim)
-End up somewhere very far from home in their quest to right their wrongs
-Have younger brothers. XD;
That's the list for now, but there's probably more to come, since I'm only in chapter 2. Isn't that freaky, though?
[EDIT] And I quote: "...[modern scientists] know that metals cannot be transmuted and the elixir of life is a chimera." This is just plain freaky. Hiromu Arakawa must have been reading a Japanese translation of Frankenstein when he made FMA or something.